英文药名：Histaglobin S.C. inj（Histamine dihydrochloride）
Histaglobin S.C. inj.
这种药物每周两次在致敏小鼠，施用3周皮下，并在50〜150毫克/公斤/天的范围由T细胞依赖性嗜酸性粒细胞浸润过敏原诱导的剂量依赖性。在这种药物为150mg/ kg /天的剂量的时间看出抑制效果大致相同施用环孢菌素为100mg/ kg /天的时间。此外，观察到的混合组分组胺和单独给药γ-球蛋白（150毫克/千克/天当量）任何抑制效果。
6瓶： 6安瓿（附 1.5毫升溶液）
Histaglobin S.C. inj.（Histamine dihydrochloride）
Histaglobin S.C. inj.（ヒスタグロビン皮下注用）
Brand name : Histaglobin S.C. inj.
Active ingredient: Histamine dihydrochloride
Dosage form: injection
Print on wrapping:
Effects of this medicine
This medicine suppresses eosinophilic infiltration which causes aggravation/chronicity of allergic symptoms. It also suppresses release of histamines which cause allergy and increases resistance to histamine.
It is usually used for allergic rhinitis, vasomotor rhinitis, allergic skin diseases (atopic dermatitis, hives, chronic eczema) and bronchial asthma.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are in state of asthma attack, just before/during menstrual period or significantly debilitated.
•If you are pregnant, possibly pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, inject subcutaneously once or twice a week for adults, once a week for children.
•In general, inject 3 or 6 times for allergic rhinitis, vasomotor rhinitis, allergic skin diseases and 6 times for bronchial asthma. The subsequent treatment span depends on your response.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include hives, rash, asthma attack, temporally aggravation of nasal symptoms, itch, cough, respiratory distress and paroxysmal sneezing. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•reduction in blood pressure, skin/mucosa (lips/nails) turning bluish-purple to dark purple, respiratory distress [shock]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•This medicine is made from blood withdrawn in Japan. Since it is blood product, the virus cleaning process is performed. Virus infection by the injection has not been observed to date. However, risk of infection through the blood products can not be ruled out.
Nippon Zoki Pharmaceutical Co., Ltd.Injection
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.