英文药名：Bonalon Tablet（Alendronate Sodium Hydrate）
Bonalon Tablet 35mg
(Alendronate Sodium Hydrate)
Monosodium trihydrogen 4-amino-1-hydroxybutane-1,1-diyldiphosphonate trihydrate
ボナロン/Bonalon is the registered trademark of Merck Sharp ＆ Dohme Corp., a subsidiary of Merck ＆ Co., Inc., Whitehouse Station, NJ, USA.
Bonalon Tablet 35mg（ボナロン錠35mg）
Brand name : Bonalon Tablet 35mg
Active ingredient: Alendronate sodium hydrate
Dosage form: white tablet, major axis: 10.3 mm, minor axis: 5.6 mm
Print on wrapping: ボナロン錠35mg（yellowish green unique sheet bound together as 1 sheet, total 2 tablets）
Effects of this medicine
This medicine is ingested into osteoclastic cells and inhibits osteoclast action to suppress borne resorption, and then increases bone mass to prevent bone fracture.
It is usually used to treat osteoporosis.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have difficulty in swallowing foods/medicines or hypocalcemia.
If you are not able to keep an upright position for at least 30 minutes.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 1 tablet (35 mg of Alendronate) at a time, once a week at the time of awakening (before breakfast) with a glass of water (approximately 180 mL). Strictly follow the instructions.
•Take this medicine on the morning of the same day of the week every week.
•Do not take this medicine with fluids other than water (never with mineral water with a high calcium/magnesium content, tea, coffee, juice, milk, etc.). Do not chew the medicine or dissolve it in mouth.
•Do not eat/drink (except water) or take other medicine at least 30 minutes after taking this medicine. Do not lie down for at least 30 minutes after taking this medicine, and keep your body in an upright position until you finish the first meal of the day. Do not take this medicine at bedtime or before waking up.
•If you miss a dose, take the missed dose the next morning (the dosage regimen is same as usual), and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally took your dose two days in a row or took 2 tablets at once, skip the next scheduled dose and return to your regular dosing schedule from the next time. If you notice any abnormality, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Maintain your oral hygiene while taking this medicine.
•When you receive dental treatment such as tooth extraction or implant, tell your dentist or oral surgeon that you are taking this medicine.
•Try to ingest calcium through meals, etc.
•Consult with your doctor of pharmacist before taking supplements containing calcium or vitamin D.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include gastric inflammation (upper abdominal pain, abdominal discomfort, nausea), indigestion (heartburn) and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•difficulty in swallowing, pain on swallowing, chest (underside of the breastbone) pain [esophageal/intraoral disorder]
•vomiting of blood, melena (black stool), pain in the pit of stomach [gastric/duodenum disorder]
•high fever, general malaise, lip erosion, bloodshot eyes, sore throat, red rash/bulla in wide area of skin [toxic epidermal necrolysis, mucocutaneous ocular syndrome]
•jaw pain/swelling/numbness, loose tooth [jaw bone necrosis, jaw osteomyelitis]
•pain of the thigh or inguinal region [atypical subtrochanteric and diaphyseal femoral fractures]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.
TEIJIN PHARMA LIMITEDInternal
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.