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当前位置:药品说明书与价格首页 >> 肿瘤 >> 淋巴瘤 >> 药品推荐 >> Endoxan(环磷酰胺原末[口服散装粉])

Endoxan(环磷酰胺原末[口服散装粉])

2015-04-22 13:55:44  作者:新特药房  来源:互联网  浏览次数:61  文字大小:【】【】【
简介: 英文药名:Endoxan(Cyclophosphamide Hydrate) 中文药名:环磷酰胺原末(口服散装粉) 日文药名:経口用エンドキサン原末 生产厂家:盐野义制药有限药品介绍类别名称烷化剂欧文商標名Endoxan一般的 ...

英文药名:Endoxan(Cyclophosphamide Hydrate)

中文药名:环磷酰胺原末(口服散装粉)

日文药名:経口用エンドキサン原末

生产厂家:盐野义制药有限
药品介绍
类别名称
烷化剂
欧文商標名
Endoxan
一般的名称:シクロホスファミド水和物(JAN)[日局]
Cyclophosphamide Hydrate
化学名:N,N-Bis(2-chloroethyl)-3,4,5,6-tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate
分子式:C7H15Cl2N2O2P・H2O
分子量:279.10
化学構造式:


性状:
白色结晶或结晶性粉末,无臭。
乙酸乙酯(100),以非常易溶,乙醇(95),并易溶于乙酸酐或氯仿,微溶于水或乙醚。
融点:45〜53℃
分配系数:4.27[1辛醇/水]
适应症
多发性骨髓瘤,恶性淋巴瘤(何杰金病,淋巴肉瘤,网状细胞肉瘤),乳腺癌
急性白血病,真性红细胞增多症,肺癌,神经肿瘤(神经母细胞瘤,视网膜母细胞瘤),骨肿瘤
但是,下面的疾病,有必要与其它抗肿瘤剂联合使用。
慢性淋巴细胞性白血病,慢性骨髓性白血病,咽癌,胃癌,胰腺癌,肝癌,结肠癌,子宫颈癌,子宫内膜癌,卵巢癌,睾丸肿瘤,滋养细胞疾病(绒毛膜癌,破坏葡萄胎,葡萄胎子宫),横纹肌肉瘤,恶性黑色素瘤
以下难治性风湿性疾病
系统性红斑狼疮,全身性血管炎(显微镜下多血管炎,武〜egena肉芽肿病,结节性多动脉炎,Churg-Strauss综合征,大动脉炎综合征,等等),多肌炎/皮肌炎,硬皮病,混合性结缔组织病和耐火风湿性疾病脉管炎。
肾病综合征(仅限于有充分的效果甚至不能在用皮质类固醇适当的治疗可以看到的情况)
【用法用量】
单独使用
成年人:每天100〜200毫克口服施用环磷酰胺(无水基)。此外,想增加或减少取决于患者的年龄和症状。
如果结合使用其它的抗肿瘤剂
将根据在单独使用时,体重减轻适当。
成年人:一天50〜100毫克口服施用环磷酰胺(无水基)。此外,增加或减少取决于患者的年龄和症状。
成年人一般口服给药8〜12周每日50〜100毫克环磷酰胺(无水基)。此外,想增加或减少取决于患者的年龄和症状。
儿童:8〜12周口服1日2〜3毫克/ kg给药环磷酰胺(酸酐当量)。此外,年龄,和将根据症状调整,且通常为1天100毫克。原则上,总剂量高达300毫克/公斤。
药效药理
药理作用
抗肿瘤药理
效应对动物移植瘤(体内)
鼠标的艾氏癌,癌症巴什福德,大鼠,沃克癌肉瘤吉田,显示对詹森肉瘤等,鼠标L1210白血病,许多其他动物的便携性肿瘤,如大鼠肝癌腹水AH13明确肿瘤的生长抑制作用承认生存优势碲。
细胞学效果(体外)
在大鼠吉田肉瘤,很短的时间周期内,减少了核分裂的试验中,异常核分裂被看见,肿胀的细胞,崩溃的细胞核,承认细胞质的熔点。
作用机序
环磷酰胺是在体内活化后,抑制肿瘤细胞的DNA合成,已发现代表的抗肿瘤作用。
在为75mg/ kg的小鼠艾氏癌(腹水型)施用腹膜内,显然是在肿瘤细胞上的核酸合成的影响被抑制两者的DNA合成和RNA被抑制更显着朝该DNA。
如果30,60,120mg/ kg的小鼠的艾氏癌(腹水型)腹膜内给药,在任何剂量下,作用于肿瘤细胞分裂周期(前期),M相的G2期(有丝分裂期)延迟过渡到并抑制所得的细胞增殖。
在为120mg/ kg剂量组还充当在S期(DNA合成期)。
包装规格:[口服环磷酰胺散装粉]
100毫克*10瓶/盒


生产商:盐野义制药有限
Endoxan(Cyclophosphamide Hydrate)-环磷酰胺
Generic Name: Cyclophosphamide
Product Name: Endoxan
Endoxan is a drug used to treat various cancerous dieases (breast and ovarian cancers, and leukaemia), disorders of the immune system (such as systemic lupus erythematosus and vasculitis). Endoxan is also used to prevent transplant rejection in some instances. If you are unsure why Endoxan has been prescribed for you, contact your doctor.
Action
Endoxan is a type of drug known as a cytotoxic agent. It works by killing rapidly dividing cells, which make it particularly useful in the treatment of certain cancers and disorders of the immune system. Unfortunately, Endoxan can also target normal rapidly dividing cells in the body, which can result in unwanted side effects such as nausea and vomiting, and hair loss.
Dose advice
•Endoxan is available only on prescription through your doctor.
•Always tell your doctor you are being treated with Endoxan before being prescribed other medication or purchasing over the counter medicines.
•Endoxan should not be used in patients with certain medical conditions – be sure to tell your doctor if you suffer from any medical conditions before being prescribed Endoxan.
•Endoxan should not be used in patients who are pregnant (ADEC Pregnancy Category D) or breastfeeding – always tell your doctor you are pregnant or breast feeding before using Endoxan.
•Report signs of infection or unusual bleeding to your doctor. Avoid people with infections while undergoing treatment with Endoxan.
•Drink plenty of fluids and urinate frequently while undergoing treatment with Endoxan.
•Report any signs of bladder irritation to your doctor.
Schedule
Schedule 4
Common side effects
All medicines may cause side effects. Your doctor has weighed out the risks against the benefits of you taking Endoxan. Consult your doctor if any of the below side effects concern you.
The following side effects occur in 1% or more of patients taking Endoxan:
•Nausea and vomiting
•Appetite loss
•Hair loss – regrowth of hair may be of a different colour or texture
•Nasal congestion (following injection only)
•Delayed wound healing
•Inflammation of the bladder – report bladder irritation or bleeding on urination to your doctor as soon as possible
•Disorders of the blood – report frequent or persistent infections to your doctor, including signs and symptoms of fever, sore throat, unusual bleeding or bruising, and fatigue.
•Infertility – there is a risk of sterility following treatment with Endoxan and this should be discussed with your doctor.
Uncommon side effects
The following side effects occur in 0.1 to 1% of patients taking Endoxan:
•Darkening of skin and fingernails.
•Taste disturbances (metallic taste or loss of taste).
Consult your doctor if you experience any of the above symptoms, or any other unusual or abnormal symptoms that concern you.
http://www.kegg.jp/medicus-bin/japic_med?japic_code=00060682
http://www.health.ne.jp/medicine/rx/622181601_34238.html

责任编辑:admin


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