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pentostatin(喷司他丁注射溶解液)

2012-08-04 11:24:53  作者:新特药房  来源:中国新特药网天津分站  浏览次数:277  文字大小:【】【】【
简介: 注射用喷司他丁(pentostatin,商品名Nipent)1998年2月经美国FDA正式批准了上市。喷司他丁是拟嘌呤类的抗肿瘤药,Nipent?为其注射用粉针制剂,主要用于干细胞白血病(hairy cell leukemia,HCL)等的治疗[ ...

部份中文喷司他汀处方资料(仅供参考)
【中文品名】喷司他汀
【药效类别】抗肿瘤药>抗代谢剂
【通用药名】PENTOSTATIN
【别  名】Coforin, YK-176
【化学名称】 Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
【CA登记号】[53910-25-1]
【结 构 式】


【分 子 式】C11H16N4O4
【分 子 量】268.27
【收录药典】
【开发单位】Yamasa Corporation
【首次上市】1996年,日本
【性  状】
【用  途】腺嘌呤脱氨酶抑制药,用于治疗成年T细胞白血病和毛细胞白血病。
【临床用途】
干细胞白血病(hairycell leukemia,HCL) 这是FDA指定的适应症。HCL是一种不常见的慢性淋巴组织增生症,多见于40~60岁的男性,曾用α干扰素或脾切除术予以治疗。喷司他丁对HCL有良好的疗效,其中完全有效率为60%,部分有效率为84%~90%。同时喷司他丁还成功地应用于那些α干扰素非应答的患者,补救率为74%~86%。
慢性淋巴细胞白血病(chromic lymphocyticleukemia,CLL)尽管喷司他丁对CLL有一定的疗效,但一般被用作二线药物,主要用于复发的Ⅲ,Ⅳ期的CLL患者。
蕈样霉菌病(mycosis fungoides) 一项二期临床实验表明,喷司他丁合用α2a干扰素对重度顽固蕈样霉菌病/红皮病有效。全部41名患者第1~3天静注喷司他丁4mg.m-2.d-1,同时肌注干扰素1×107u.m-2连续22d,第23~26天肌注干扰素5×107u.m-2,结果总有效率为41%。

コホリン静注用7.5mg

ペントスタチン(代謝拮抗剤)商品名(製造・販売会社)
•コホリン(化学及血清療法研究所、日本化薬)
フルダラビンやメルカプトプリンと同じプリン代謝拮抗剤で、DNA合成に関与している酵素の働きを阻害することで、抗がん作用を発揮します。
多くのリンパ系腫瘍に有効性が認められていますが、特にヘアリーセル白血病に対して高い効果を発揮するとされています。
適応となるがん
成人T細胞白血病リンパ腫、ヘアリーセル白血病
主な副作用
腎不全や重度の腎障害、骨髄抑制による感染症や出血傾向、貧血などに注意が必要です。一般的な副作用としては、吐き気・嘔吐、食欲不振などの消化器症状がみられるほか、肝障害、倦怠感なども多いとされています。
使用上の注意点
アルキル化剤シクロホスファミドやイホスファミドとの併用で錯乱や呼吸困難があらわれることがあります。本剤は正常細胞を傷害して重篤な副作用を引き起こすことがあります。副作用は使用後数ヶ月~数年もしてから生じることもあるとされており、医療機関での慎重な使用が必要とされています。


完整处方资料附件:http://www.info.pmda.go.jp/go/pack/4291404D1038_2_05/4291404D1038_2_05?view=body
美国FDA正式批准了注射用喷司他丁(pentostatin,商品名Nipent)上市。喷司他丁是拟嘌呤类的抗肿瘤药,Nipent为其注射用粉针制剂,主要用于干细胞白血病(hairycell leukemia,HCL)等的治疗。
Pentostatin is an antibiotic chemotherapy drug. It is most commonly used to treat hairy cell leukemia, a form of cancer in which the patient has too many abnormal B lymphocytes. Another frequent use is to treat chronic lymphocytic leukemia. Pentostatin may also be administered to patients with lymphoma or other kinds of leukemia. It is marketed under the brand name Nipent®.
The drug attempts to stop or impede the production of cancerous cells by slowing the production of DNA. It does this by blocking the production of an element called ribonucleotide reductase. This helps to prevent cell division, which is more active in cancerous cells. While the drug does cause DNA damage, it does not tend to have as strong an effect on the development of normal cells as they do not need to divide as frequently.
Pentostatin is typically administered by a trained professional in a medical facility. It comes as a powder, which is mixed with sterile fluid and given intravenously (IV). The therapy usually consists of biweekly treatments administered over the course of approximately three to six months.
-------------------------------------------
Patients who are undergoing pentostatin treatment will often have a decrease in blood cells. For this reason, many doctors will test blood cell levels before, during and after the drug therapy. Some drugs may also increase the risk of taking pentostatin, including aspirin, allopurinal, fludarabine, and vidarabine. Women are typically advised not to get pregnant while undergoing treatment. Receiving vaccinations of any kind while taking the drug may also increase the risk of an adverse reaction.
There are many common side effects of taking pentostatin, including loss of appetite, upset stomach, vomiting, and nausea. Some patients may also experience gas, diarrhea, and pain in the abdomen. There have also been reports of headaches and changes in the teeth and gums. These effects are usually not serious but should be discussed with a doctor if they become more severe or do not go away. Blistering in the mouth or uncharacteristic fatigue are more serious and should be discussed with a doctor if they worsen or persist.
The more serious side effects of taking pentostatin should be discussed with a doctor as soon as possible. These include aching muscles, chills, and fever. Pain in the eyes, ears, throat, or chest should also receive treatment. Some patients also report dizziness, insomnia, depression, and anxiety.

责任编辑:admin


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